Prof. Liqing Chen

Liqing Chen, Ph.D.

Associate Research Professor
Department of Chemistry
Graduate Faculty of Biotechnology, Chemistry and Materials Science
Associate Director and Head of X-Ray Crystallography
Laboratory for Structural Biology
Materials Science Building, Room 239
University of Alabama in Huntsville
Huntsville, AL 35899
Phone: (256) 824-6278
Fax: (256) 824-6349


Educational Background:

Professional Experience:

Awards and Honors:

Research Interests:

Research interests:
X-ray crystallography; structural biology; structure-based drug design, lead discovery and optimization;


  1. Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD. Chuanbing Bian, Cai Yuan, Liqing Chen, Edward J. Meehan, Longguang Jiang, Zixiang Huang, Lin Lin and Mingdong Huang, Proteins 78, 1601-1605 (2010).
  2. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. Zhuo Liu, Lin Lin, Cai Yuan, Gerry A. F. Nicolaes, Liqing Chen, Edward J. Meehan, Bruce Furie, Barbara Furie and Mingdong Huang, J. Biol. Chem. 285, 8824-8829 (2010).
  3. Structural basis of transport of lysophospholipids by human serum albumin. Shihui Guo, Xiaoli Shi, Feng Yang, Liqing Chen, Edward J. Meehan, Chuanbing Bian and Mingdong Huang, Biochem. J. 423, 23-30 (2009).
  4. Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity. Yujun Wang, Li Qiu, Hilary Ranson, Nongkran Lumjuan, Janet Hemingway, William N. Setzer, Edward J. Meehan and Liqing Chen, J. Struct. Biol. 164, 228-235 (2008).
  5. Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. Xiaomin Hou, Edward J. Meehan, Jieming Xie, Mingdong Huang, Minghuang Chen and Liqing Chen, J. Struct. Biol. 164, 81-87 (2008).
  6. A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. Lili Zhu, Feng Yang, Liqing Chen, Edward J. Meehan and Mingdong Huang, J. Struct. Biol. 162, 40-49 (2008).
  7. 1,7-Dihydroxy-2,3,4-trimethoxy-9H-xanthen-9-one monohydrate from Halenia elliptica. Peizhong Yu, Xiaojuan Shen, Changqi Hu, Edward J. Meehan and Liqing Chen, Acta Cryst. E64, o651-o652 (2008).Reprint (PDF file)
  8. Crystallization and preliminary crystallographic analysis of beta-trichosanthin, an isoform of trichosanthin from the root tuber of Trichosanthe kirilowii. Xiaomin Hou, Minghuang Chen, Qi Peng, Liqing Chen, Edward J. Meehan and Mingdong Huang, Chinese J. Struct. Chem.  26, 1303-1307 (2007).Reprint (PDF file)
  9. X-ray sequence and crystal structure of luffaculin I, a novel type I ribosome-inactivating protein. Xiaomin Hou, Minghuang Chen, Liqing Chen, Edward J. Meehan, Jieming Xie and Mingdong Huang, BMC Structural Biology 7:29 (2007). Abstract and Reprint (PDF file).
  10. X-ray structure and antioxidant activity of salidroside, a phenylethanoid glycoside. Peizhong Yu, Changqi Hu, Edward J. Meehan and Liqing Chen, Chemistry & Biodiversity 4, 508-513 (2007). Abstract and Reprint (PDF file).
  11. An-anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope. Yongdong Li, Graham Parry, Liqing Chen, Jennifer A. Callahan, David E. Shaw, Edward J. Meehan, Andrew P. Mazar and Mingdong Huang, J. Mol. Biol. 365, 1117-1129 (2007). Abstract and Reprint (PDF file).
  12. Crystallization and preliminary crystallographic studies of Luffaculin 1, a ribosome-inactivating protein from the seeds of Luffa Acutangula. Xaio-Min Hou, Ming-Huang Chen, Jie-Ming Xie, Xiao-Ming Ye, Geng-Xiang Zhao, Feng Yang, Li-Qing Chen, Ming-Dong Huang, Chinese J. Struct. Chem. 25, 1035-1038 (2006). Reprint (PDF file).
  13. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. Liqing Chen, Yujun Wang, David Wells, Diana Toh, Hunt Harold, Jing Zhou, Enrico DiGiammarino and Edward J. Meehan, Acta Crystallographica F62, 844-848 (2006). Abstract and Reprint (PDF file).
  14. An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+. Yijian Rao, Chuanbing Bian, Cai Yuan, Yongdong Li, Liqing Chen, Xiaoming Ye, Zixiang Huang, Mingdong Huang, Biochem. & Biophys. Res. Commun. 348, 908-915 (2006). Abstract and Reprint (PDF file).
  15. Structure of human urokinase plasminogen activator in complex with its receptor. Qing Huai, Andrew P. Mazar, Alice Kuo, Graham C. Parry, David E. Shaw, Jennifer Callahan, Yongdong Li, Cai Yuan, Chuanbing Bian, Liqing Chen, Bruce Furie, Barbara C. Furie, Douglas B. Cines, Mingdong Huang, Science 311, 656-659 (2006). Abstract, Reprint (PDF file) and Supporting Online Material (PDF file).
  16. Mutation of a conserved tryptophan in the chitin-binding cleft of S. marcescens chitinase A enhances transglycosylation. Nathan N. Aronson, Jr., Brian A. Halloran, Mikhail F. Alexyev, Xiaoyin E. Zhou, Yujun Wang, Edward J. Meehan & Liqing Chen, Biosci., Biotechnol., and Biochem. 70, 243-251 (2006). Abstract.
  17. Optimization of crystals of an inhibitory antibody of urokinase plasminogen activator receptor (uPAR) with hydrogen peroxide and low protein concentration. Yongdong Li, Xiaoli Shi, Graham Parry, Liqing Chen, Jennifer A. Callahan, Andrew P. Mazar & Mingdong Huang, Protein Pept. Lett. 12, 655-658 (2005). Abstract.
  18. High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target. Liqing Chen, Enrico DiGiammarino, Xiaoyin E. Zhou, Yujun Wang, Diana Toh, Thomas W. Hodge & Edward J. Meehan, J. Biol. Chem. 279, 40204-40208 (2004).Abstract and Reprint (PDF file)
  19. The hyperthermophile protein Sso10a is a dimer of winged helix DNA-binding domains linked by an antiparallel coiled coil rod.Liqing Chen,Li-Rong Chen, Xiaoyin E. Zhou, Yujun Wang, Mebrahtu Kahsai, Andrew T. Clark, Stephen P. Edmondson, Zhi-Jie Liu, John P. Rose, Bi-Cheng Wang, Edward J. Meehan & John W. Shriver, J. Mol. Biol.  341, 73-91 (2004). Abstract and Reprint (PDF file)
  20. Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain. Shanyun Lu, Jindrich Symmersky, Songlin Li, Mike Carson, Liqing Chen, Edward Meehan & Ming Luo, Proteins: Structure, Function, and Bioinfomatics 56, 384-386 (2004).Abstract
  21. Crystal structure of Type IIE restriction endonuclease EcoRII reveals an autoinhibition mechanism by a novel effector-binding fold. Xiaoyin E. Zhou, Yujun Wang, Monika Reuter, Merlind Mücke, Detlev H. Krüger, Edward J. Meehan & Liqing Chen, J. Mol. Biol. 335, 307-319 (2004). Abstract and Reprint (PDF file)
  22. Crystal structure of an insect delta-class glutathione S-transferase from a DDT- resistant strain of the malaria vector Anopheles gambiae. Liqing Chen, Pamela R. Hall, Xiaoyin E. Zhou, Hilary Ranson, Janet Hemingway & Edward J. Meehan, Acta Crystallographica D59, 2211-2217 (2003). Abstract and Reprint (PDF file)
  23. A single mutation of restriction endonuclease EcoRII led to a new crystal form that diffracts to 2.1 [A] resolution. Xiaoyin E. Zhou, Yujun Wang, Monika Reuter, Petra Mackeldanz, Detlev H. Kruger, Edward J. Meehan & Liqing Chen, Acta Crystallographica D59, 910-912 (2003). Abstract and Reprint (PDF file)
  24. Molecular replacement studies of cucurmosin from cucurbita moschata: structure homology with trichosanthin. Shi Xiao-Li, Edward X. Zhou, Ye Xiao-Ming, Edward J. Meehan, Chen Ming-Huang & Liqing Chen, Chinese J. Struc. Chem. 22, 165-168 (2003).
  25. A new crystal form of restriction endonuclease EcoRII that diffracts to 2.8 [A] resolution. Edward X. Zhou, Monika Reuter, Edward J. Meehan & Liqing Chen. Acta Crystallographica D58, 1343-1345 (2002). Abstract and Reprint (PDF file)
  26. Crystallization and preliminary X-ray diffraction analysis of protein L-isoaspartyl O-methyltransferase from wheat germ. Michelle D. Amaral, Liqing Chen, Debasish Chattopadhyay, Craig D. Smith & Edward J. Meehan, Acta Crystallographica D57, 304-305 (2001). Abstract
  27. Crystallization of agGST1-6, a recombinant glutathione S-transferase from a DDT-resistant strain of Anopheles gambiae. Pamela H. Roberts, Xiaoyin Zhou, Anna M. Holmes, Hilary Ranson, Graham Small, Janet Hemingway, Joseph D. Ng, Liqing Chen & Edward J. Meehan, Acta Crystallographica D57, 134-136 (2001). Abstract
  28. Triterpenoid constituents in the bark of Balanops australiana. William N. Setzer, Mary C. Setzer, R. Lynton Peppers, Michael B. McFerrin, Edward J. Meehan, Liqing Chen, Robert B. Bates, Pichaya Nakkiew and Betsy R. Jackes, Aust. J. Chem. 53, 809-812 (2000).
  29. Crystallization and preliminary X-ray diffraction analysis of restriction endonuclease EcoRII. Elisavetta A. Karpova, Edward Meehan, Marc L. Pusey & Liqing Chen, Acta Crystallographica D55, 1604-1605 (1999). Abstract
  30. Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, North Queensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate. William N. Setzer, Mary C. Setzer, Robert B. Bates, Pichaya Nakkiew, Betsy R. Jackes, Liqing Chen, Michael B. McFerrin & Edward J. Meehan, Planta Medica 65(8), 747-749 (1999). Abstract
  31. Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Li Su, Liqing Chen, Martin Egli, James M. Berger & Alexander Rich, Nature Structural Biology 6(3), 285-292 (1999). Cover Picture and Review (PDF file) and Abstract and Reprint (PDF file)
  32. Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere. Li Cai, Liqing Chen, Sridharan Raghavan, Robert Ratliff, Robert Moyzis & Alexander Rich, Nucleic Acids Research 26(20), 4696-4705 (1998). Abstract & reprint
  33. Energetics of the lattice: packing elements in crystals of four- stranded intercalated cytosine-rich DNA molecules. Imre Berger, Li Cai, Liqing Chen & Alexander Rich, Biopolymers: Nucl. Acid Sci. 44(3), 257-267 (1997). Abstract & reprint
  34. 3-D structure of the D153G mutant of E. coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity. Chris G. Dealwis, Liqing Chen, Cathy Brennan, Wlodek Mandecki & Cele Abad-Zapatero, Protein Engineering 8, 865-871 (1995). Abstract
  35. Crystal structure of a four-stranded intercalated DNA: d(C4). Liqing Chen, Li Cai, Xiaohua Zhang & Alexander Rich, Biochemistry 33, 13540-13546 (1994).Abstract
  36. Crystal structure of recombinant human platelet factor 4. Xiaohua Zhang, Liqing Chen, Daniel Bancroft, C. K. Lai & Theodore Maione, Biochemistry 33, 8361-8366 (1994).Abstract
  37. Three-dimensional structure of a mutant (Asp101->Ser) of E. coli alkaline phosphatase with higher catalytic efficiency. Liqing Chen, David J. Neidhart, William M. Kohlbrenner, Wlodek Mandecki, Sean Bell, Janusz Sowadski & Cele Abad-Zapatero, Protein Engineering 5, 605-610 (1992). Cover Picture and Abstract
  38. The structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor. Liqing Chen, John W. Erickson, Timothy J. Rydel, Chang H. Park, David J. Neidhart, Jay Luly & Cele Abad-Zapatero, Acta Cryst. B48, 476-488 (1992).Abstract
  39. Crystal structure of a bovine neurophysin-II dipeptide complex at 2.8A determined from the single-wavelength anomalous scattering signal of an incorporated iodine atom. Liqing Chen, John Rose, Esther Breslow, Daniel Yang, Wen-Rui Chang, William Furey, Jr., Martin Sax & Bi-Cheng Wang, Proc. Natl. Acad. Sci. U.S.A. 88, 4240- 4244 (1991).Abstract & reprint
  40. A new crystal form of ricin-OR. Wen-rui Chang, Liqing Chen, John Rose, Chin Hsuan Wei, Leatrice Abrams, Martin Sax & Bi-Cheng Wang, Eur. J. Biochem. 180, 327-328 (1989).Abstract
  41. Crystal structure of bis(n5-cyclopentadienyl-n6-tetrahydronaphthaleneiron(II)) dodecahydrododecaborate (C15H17Fe+)2B12H122-. Liqing Chen, Kezhen Pan, Lun Zhang & Peizhi Hu, Chinese J. Struc. Chem. 3(1), 1-4 (1984).
  42. Crystal structure of bis(n5-cyclopentadienyl-n6-isopropylbenzene-iron(II)) dodecahydrododecaborate (C14H17Fe+)2B12H122-. Liqing Chen, Kezhen Pan, Lun Zhang & Peizhi Hu, Chinese J. Struc. Chem. 3(1), 5-8 (1984).
  43. Crystal structure of bis(n5-cyclopentadienyl-1,3-propanediyl- bis(diphenylphosphine(-P,P')) nickel(II)) dodecahydrododecaborate (C5H5Ni(C6H5)2PC3H6P(C6H5)2+)2B12H122-. Liqing Chen, Kezhen Pan, Xinlan Chen & Lun Zhang, Chinese J. Struc. Chem. 3(2), 125-128 (1984).